Extensively overlapping reading frames in a second mammalian gene
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چکیده
منابع مشابه
Extensively overlapping reading frames in a second mammalian gene.
Given the roominess of the mammalian genome, the discovery of a gene that saves space by being translated in two reading frames over a distance of 356 codons is unexpected. Klemke et al. (2001) have found that the rat XLαs gene, previously shown to encode a G protein α subunit, encodes a second protein— dubbed ALEX—in the +1 reading frame. The start codon for ALEX (AUGALEX) is 32 nt downstream ...
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The >1 kb XL-exon of the rat XLalphas/Galphas gene encodes the 37 kDa XL-domain, the N-terminal half of the 78 kDa neuroendocrine-specific G-protein alpha-subunit XLalphas. Here, we describe a novel feature of the XL-exon, the presence of an alternative >1 kb open reading frame (ORF) that completely overlaps with the ORF encoding the XL-domain. The alternative ORF starts 32 nucleotides downstre...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2001
ISSN: 1469-221X,1469-3178
DOI: 10.1093/embo-reports/kve183